منابع مشابه
Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes
OBJECTIVES To investigate a B-cell-depleting strategy to reverse diabetes in naïve NOD mice. RESEARCH DESIGN AND METHODS We targeted the CD22 receptor on B-cells of naïve NOD mice to deplete and reprogram B-cells to effectively reverse autoimmune diabetes. RESULTS Anti-CD22/cal monoclonal antibody (mAb) therapy resulted in early and prolonged B-cell depletion and delayed disease in pre-diab...
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We examined the therapeutic effects of C-peptide on established nociceptive neuropathy in type 1 diabetic BB/Wor rats. Nociceptive nerve function, unmyelinated sural nerve fiber and dorsal root ganglion (DRG) cell morphometry, nociceptive peptide content, and the expression of neurotrophic factors and their receptors were investigated. C-peptide was administered either as a continuous subcutane...
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Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH). The mitochondrial protonophore 2,4 dinitrophenol (DNP) has beneficial effects on NAFLD, insulin resistance, and obesity in preclinical models but is too toxic for clinical use. We developed a controlled-release oral formulation of DNP, called CRMP (con...
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Saleh A. and M. Pagés (2003): Plant AP2/ERF transcription factors. – Genetika, Vol. 35, No. 1, 37-50. Transcription factors (TFs) play important roles in plant development and its response to the biotic and abiotic stresses. AP2/ERF transcription factors family is unique to plants and a conserved AP2/ERF domain of about 60 amino acids characterized these transcription factors. AP2/ERF genes hav...
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In APCs, the protein tyrosine kinase Syk is required for signaling of several immunoreceptors, including the BCR and FcR. We show that conditional ablation of the syk gene in dendritic cells (DCs) abrogates FcgammaR-mediated cross priming of diabetogenic T cells in RIP-mOVA mice, a situation phenocopied in wild-type RIP-mOVA mice treated with the selective Syk inhibitor R788. In addition to blo...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2016
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd.2016.4